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Common Oral Antianginal Drugs

Obat-Obat Anti Angina 

Drug Usual Dose Comments; Adverse Effects
Nitroglycerin 0.4–0.6 mg SL Aborts acute attacks; headaches, hypotension
Nitroglycerin 1–3 mg buccal Larger tablet for handicapped patients
Nitroglycerin 0.4 mg spray More convenient than pills
Nitroglycerin 0.5–2 in of 2% ointment Prophylactic therapy; tolerance a problem
Nitroglycerin 0.1–0.6 mg/h patches Prophylactic therapy; tolerance a problem
Isosorbide dinitrate 10–60 mg three times daily Need 8 h off q24h to avoid tolerance
Isosorbide mononitrate 20 mg twice daily Take 7 h apart
Drug   Daily Dosage (mg)   Comments; Adverse Effects  
Propranolol 160–320 CNS side effects—fatigue, impotence—common
Nadolol 80–240 Long half-life, noncardioselective
Timolol 10–45 Noncardioselective
Metaprolol 100–400 Cardioselective
Atenolol 50–200 Cardioselective
Acebutolol 400–1200 Cardioselective, some intrinsic sympathomimetic activity
Betaxolol 5–40 Cardioselective, long half-life
Bisoprolol 5–20 Cardioselective
Pindolol 5–40 Marked intrinsic sympathomimetic activity
Calcium Channel Blockers, Heart Rate Lowering  
Diltiazem 120–360 Heart-rate lowering; AV block, heart failure, edema
Verapamil 120–480 Heart-rate lowering; AV block, heart failure, constipation
Dihydroperidine Calcium Channel Blockers  
Amlodipine 5–10 Least myocardial depression
Nifedipine 30–60 Hypotension, tachycardia
Nicardipine 60–120 Potent coronary vasodilator
Felodipine 5–20 High vascular selectivity
Isradipine 2.5–10 Potent coronary vasodilator
Nisoldipine 10–40 Similar to nifedipine
Sodium Current Inhibitor  
Ranolazine 1000–2000 mg May increase QT interval on ECG

Current Diagnosis & Treatment Cardiology 3rd Edition (McGraw-Hill) 2009

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