Diagnosis Banding Hepatitis Kronik
| Diagnosis | Screening Tests | Confirmatory Tests (Serum or Liver) | Comments |
|---|---|---|---|
| Chronic hepatitis B | HBsAg | HBV DNA, HBeAg, or HBcAg in liver |
|
| Chronic hepatitis C | Anti-HCV | HCV RNA (using PCR) | Immunoblot for anti-HCV can be used to confirm antibody reactivity |
| Chronic hepatitis D | Anti-HDV | HDV RNA or HDV antigen in the liver | |
| Autoimmune hepatitis | ANA (anti-LKM1) | Exclusion of other causes and patterns of clinical disease | Suggested by raised IgG levels and by response to corticosteroid therapy |
| Drug-induced liver disease | History | Rechallenge, if necessary, is considered safe | Medications most suspected include isoniazid, NSAIDs, methyldopa, nitrofurantoin |
| Wilson's disease | Ceruloplasmin | Urine and hepatic copper concentration | Suggested by hemolysis or severe chronic hepatitis in a child or adolescent |
| Cryptogenic | Exclusion of other causes | Major differential is with autoimmune hepatitis and drug-induced liver disease |