Correlations Between CD4 Count and HIV-Associated Diseases

CD4 Count > 500 cells/mm3

• Acute primary infection
• Recurrent vaginal candidiasis
• Persistent generalised lymphadenopathy

CD4 Count < 500 cells/mm3

• Pulmonary tuberculosis
• Pneumococcal pneumonia
• Herpes zoster
• Oropharyngeal candidiasis
• Oral hairy leucoplakia
• Extra-intestinal salmonellosis
• Kaposi's sarcoma
• HIV-associated idiopathic thrombocytopenic purpura
• Cervical intra-epithelial neoplasia II-III
• Lymphoid interstitial pneumonitis

CD4 Count < 200 cells/mm3

• Pneumocystis carinii (jirovecii) pneumonia
• Mucocutaneous herpes simplex
• Cryptosporidium
• Microsporidium
• Oesophageal candidiasis
• Miliary/extrapulmonary tuberculosis
• HIV-associated wasting
• Peripheral neuropathy

CD4 Count < 100 cells/mm3

• Cerebral toxoplasmosis
• Cryptococcal meningitis
• Primary CNS lymphoma
• Non-Hodgkin lymphoma
• HIV-associated dementia
• Progressive multifocal leucoencephalopathy

CD4 Count < 50 cells/mm3

• CMV retinitis/gastrointestinal disease
• Disseminated Mycobacterium avium intracellulare

Referensi:
Davidson's Principles & Practice of Medicine 20th Edition (Churchill Livingstone) 2007

Tags: Lecture Notes