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Drugs That Have Been Associated with Significant Effects on Some Nursing Infants

Obat-Obatan yang Sebaiknya Dihindari oleh Ibu Menyusui



Drug

Reported Effecta

Acebutolol

Hypotension, bradycardia, tachypnea

5-Aminosalicylic acid

Diarrhea (one case)

Atenolol

Cyanosis, bradycardia

Bromocriptine

Suppresses lactation, may be hazardous to the mother

Aspirin (salicylates)

Metabolic acidosis (one case)

Clemastine

Drowsiness, irritability, refusal to feed, high-pitched cry, neck stiffness (one case)

Ergotamine

Vomiting, diarrhea, convulsions—doses used in migraine medications

Lithium

A third to half therapeutic blood concentration in infants

Phenindione

Anticoagulant—increased prothrombin and partial thromboplastin time in one infant—not used in United States

Phenobarbital

Sedation; infantile spasms after weaning from milk containing phenobarbital; methemoglobinemia (one case)

Primidone

Sedation, feeding problems

Sulfasalazine

Bloody diarrhea (one case)


aBlood concentration in the infant may be of clinical importance.





Referensi:
Williams Obstetrics 23rd Edition (McGraw-Hill) 2009
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